高歌 研究员

高歌 研究员

计算基因组学研究组

北京大学 生命科学学院 研究员,博士生导师

电话:010-62755206

传真:010-62755206

E-mail:gaog@mail.cbi.pku.edu.cn

1.组学大数据的整合与挖掘

2.长非编码RNA 、转录因子等重要转录调控因子的功能与演化


“工欲善其事,必先利其器”,有效的新工具是获得新发现的重要保障,海量的生物学数据急需好的生物信息学技术。课题组坚持立足国内,瞄准生物信息学研究国际前沿开展研究工作,针对以深度测序为代表的新兴生物学大数据开发了12个生物信息新算法、数据库与大数据分析技术。自2011年来,相关网站累计外部有效访问量达3.6亿次,其中三分之二来自海外,在生物信息学领域有较强国际影响力;其间作为主要作者于生物信息学与基因组学领域权威杂志上发表15篇研究论文,其中3篇被评列为ESI Highly Cited (Top 1%) Paper,引用数于本领域过去10年所有SCI收录论文中位列前1%;2篇分别入选InCoB’16 Best Paper及Faculty of 1000 Very Good Paper,另外3篇被相应杂志标为Highly Accessed Paper,获得国内外同行广泛关注;同时作为生物信息分析合作者在Cell, Cell Stem Cell, Developmental Cell, Nature Communication 等杂志发表论文12篇。


1.Cheng SJ, Shi FY, Liu H, Ding Y, Jiang S, Liang N, Gao G. (2017) Accurately annotate compound effects of genetic variants using a context-sensitive framework. Nucleic Acids Res., 45: e82.

2.Jin J, Tian F, Yang DC, Kong L, Gao G. (2017) PlantTFDB 4.0: towards a central hub for transcription factors and regulatory interactions in plants. Nucleic Acids Res. 45: D1040-D1045.

3.Hou M, Tian F, Jiang S, Kong L, Yang DC, Gao G. (2016) LocExpress: a web server for efficiently estimating expression of novel transcripts. BMC Genomics, 17: 175-179

4.Hu B, Jin J, Guo A, Zhang H, Luo J, Gao G. (2014) GSDS 2.0: an upgraded gene feature visualization server. Bioinformatics, 31: 1296-1297

5.Zhao Y, Tang L, Li Z, Jin J, Luo J, Gao G. (2015) Identification and analysis of unitary loss of long-established protein-coding genes in Poaceae shows evidences for biased gene loss and putatively functional transcription of relics. BMC Evol. Biol., 15: 66.

6.Jin J, He K, Tang X, Li Z, Lv L, Zhao Y, Luo J, Gao G. (2015) An Arabidopsis transcriptional regulatory map reveals distinct functional and evolutionary features of novel transcription factors. Mol. Biol. Evol., 32: 1767-1773.

7.Jin J, Zhang H, Kong L, Gao G, Luo J. (2014) PlantTFDB 3.0: a portal for the functional and evolutionary study of plant transcription factors. Nucl. Acids Res., 42: D1182-1187.

8.Xiao A, Cheng Z, Kong L, Zhu Z, Lin S, Gao G, Zhang B. (2014) CasOT: a genome-wide Cas9/gRNA off-target searching tool. Bioinformatics, 30: 1180-1182.

9.Gao G, Vibranovski MD, Zhang L, Li Z, Liu M, Zhang Y, Li XM, Zhang WX, Fan Q, Long M, Wei L. (2014) A long term demasculinization of X-linked intergenic noncoding RNAs in Drosophila melanogaster. Genome Res., 24: 629-638.

10.Kong L, Wang J, Zhao S, Gu X, Luo J, Gao G. (2012) ABrowse - a customizable next-generation genome browser framework. BMC Bioinformatics, 13: 2.



任立晨、孔雷、唐汶、林媛、靳进朴、王倩、梁楠、丁阳、孟宇琦、程斯进、亢雨笺、降帅、史方圆、柯岚、田丰、孙怀远、李静一、曹智杰、温正扬、王宇、杨德昌